Neoj4 and SARMIX Model for Optimizing Product Placement and Predicting the Shortest Shopping Path

Product placement of top-selling items in highly visible aisles inside supermarkets plays a crucial role in enhancing customer shopping experience. Moreover, it is important for retailers to assure that their customers can effortlessly navigate the store and locate the items they are searching for in a timely manner. The research proposes a novel and effective approach that combines two methods; the SARIMAX model for forecasting sales of each product based on historical data; by using the predicted result, placing the most demanding item in highly visible aisles. And the use of Graph Database Management Systems (GDBMS) such as Neo4j to find the shortest path for consumers to navigate throughout the store to finish the shopping as per their shopping list. By leveraging the power of data analytics and machine learning, retailers can make data-driven decisions that result in improved sales andcustomer satisfaction. Retailers investing in these technologies and strategies will likely see a significant increase in customer satisfaction and sales

Molecular detection, quantification, and isolation of Streptococcus gallolyticus bacteria colonizing colorectal tumors: inflammation-driven potential of carcinogenesis via IL-1, COX-2, and IL-8

<p>Abstract</p> <p>Background</p> <p>Colorectal cancer (CRC) has long been associated with bacteremia and/or endocarditis by <it>Streptococcus gallolyticus </it>member bacteria (SGMB) but the direct colonization of SGMB along with its molecular carcinogenic role, if any, has not been investigated. We assessed the colonization of SGMB in CRC patients with history of bacteremia (CRC-w/bac) and without history of bacteremia (CRC-wo/bac) by isolating SGMB from feces, mucosal surfaces of colorectum, and colorectal tissues and detecting SGMB DNA, via PCR and in situ hybridization (ISH) assays targeting <it>SodA </it>gene in colorectal tissues. Moreover, mRNA of IL1, IL-8, COX-2, IFN-γ, c-Myc, and Bcl-2 in colorectal tissues of studied groups was assessed via ISH and RT-PCR.</p> <p>Results</p> <p>SGMB were found to be remarkably isolated in tumorous (TU) and non-tumorous (NTU) tissues of CRC-w/bac, 20.5% and 17.3%, and CRC-wo/bac, 12.8% and 11.5%, respectively while only 2% of control tissues revealed SGMB (P < 0.05); such contrast was not found in mucosal and fecal isolation of SGMB. The positive detection of SGMB DNA in TU and NTU of CRC-w/bac and CRC-wo/bac via PCR, 48.7%, 35.9%, 32.7%, and 23%, respectively, and ISH, 46.1%, 30.7%, 28.8%, and 17.3%, respectively, was higher than in control tissues, 4 and 2%, respectively (P < 0.05). SGMB count measured via quantitative PCR of SGMB DNA in terms of copy number (CN), in TU and NTU of CRC-w/bac and CRC-wo/bac, 2.96-4.72, 1.29-2.81, 2.16-2.92, and 0.67-2.07 log₁₀CN/g respectively, showed higher colonization in TU than in NTU and in CRC-w/bac than in CRC-wo/bac (P < 0.05). The PCR-based mRNA ratio and ISH-based percentage of positively stained cells of IL-1, 1.77 and 70.3%, COX-2, 1.63 and 44.8%, and IL-8, 1.73 and 70.3%, respectively, rather than IFN-γ, c-Myc, and Bcl-2, were higher in SGMB positive patients than in control or SGMB negative patients (P < 0.05).</p> <p>Conclusions</p> <p>The current study indicated that colorectal cancer is remarkably associated with SGMB; moreover, molecular detection of SGMB in CRC was superior to link SGMB with CRC tumors highlighting a possible direct and active role of SGMB in CRC development through most probably inflammation-based sequel of tumor development or propagation via, but not limited to, IL-1, COX-2, and IL-8.</p

The association of Streptococcus bovis/gallolyticus with colorectal tumors: The nature and the underlying mechanisms of its etiological role

Streptococcus bovis (S. bovis) bacteria are associated with colorectal cancer and adenoma. S. bovis is currently named S. gallolyticus. 25 to 80% of patients with S. bovis/gallolyticus bacteremia have concomitant colorectal tumors. Colonic neoplasia may arise years after the presentation of bacteremia or infectious endocarditis of S. bovis/gallolyticus. The presence of S. bovis/gallolyticus bacteremia and/or endocarditis is also related to the presence of villous or tubular-villous adenomas in the large intestine. In addition, serological relationship of S. gallolyticus with colorectal tumors and direct colonization of S. gallolyticus in tissues of colorectal tumors were found. However, this association is still under controversy and has long been underestimated. Moreover, the etiological versus non-etiological nature of this associationis not settled yet. Therefore, by covering the most of up to date studies, this review attempts to clarify the nature and the core of S. bovis/gallolyicus association with colorectal tumors and analyze the possible underlying mechanisms

Analysis of the Effects of Rainfall, Land Use Changes, and Amount of Water Usage on Groundwater Level Decreasing (Study in Gedebage)

Sustainable urban development has been one of the main concerns for policy-makers. Increasing rate of population and urbanization have resulted in several socio-environmental impacts on people. Hence, water resources management in cities, as one of the most vital strategies, has become more complicated and challenging. In this study, the impact of precipitation, land-use changes, and amount of groundwater usageon groundwater level fluctuations was assessed. Using precipitation, remote sensing maps data from satellites, data of groundwater level, and land-use was extracted and processed by different formula and mapping tools. Gedebage Area in Bandung, Indonesia was selected as the case study location. The potential impacts of urban development in this city on groundwater resources were studied. The results suggest that from 2014 to 2018, Groundwater level decreasion was to increase simultaneously with run off discharge. Society perception confirmed that 95% is affected by precipitation, landuse change and amount of water usage at significance <0.05 while this change rate was more intense during previous decades and is predicted to be increased by 2030. Since relationship between precipitation, land-use change and amount of groundwater usage on groundwater level decreasion is undeniable, novel methodology of this stsudy can be employed for other fast-growing cities in Indonesia

Keberlanjutan Instalasi Pengolahan Air Limbah Domestik (Ipal) Berbasis Masyarakat, Gunung Kidul, YOGYAKARTA

Aplikasi teknologi dengan memperhatikan aspek komunitas menjadi salah satu faktor yang signifikan dalam keberlangsungan instalasi pengolahan air limbah. Penelitian ini dilakukan pada Dusun Mendak Giri Sekar, Kecamatan Gunung Kidul dengan kapasitas untuk dua RT(62 KK). Studi ini melihat aspek sosial, ekonomi, dan lingkungan dari proses pembangunan hingga pengoperasian IPAL yang dilakukan oleh warga. Kajian kelayakan lingkungan dilakukan dengan menganalisis efluent limbah domestik di IPAL. Studi dilakukan dengan survey lapangan dan wawancara terhadap masyarakat beserta tokoh penanggungjawab daerah. Penelitian ini menganalisis faktor-faktor penting yang berhubungan dalam pembangunan dan pengoperasian IPAL beserta menganalisis tingkat keberlanjutan teknologi melihat dari peran masyarakat, pemerintah, dan stakeholder. Sehingga, peningkatan pemberdayaan masyarakat menjadi salah satu tolak ukur kesuksesan dalam mengelola dan mengentaskan permasalahan sanitasi yang ada di Indonesia. Pada tahap pembangunan hingga pengoperasian, sudah melibatkan partisipasi masyarakat. Retribusi IPAL menjadi kesepakatan mufakat yang diterapkan di desa ini. Selain itu, analisis kualitas yang dilakukan telah memenuhi parameter kualitas air limbah. Dengan adanya penggunaan IPAL masyarakat dapat merasakan lingkungan menjadi lebih baik, sehingga menimbulkan rasa kepemilikan oleh warga

Knowledge Regarding Secondary Prevention Lifestyle Practices Among Patients with Ischaemic Heart Disease in Oman : Pilot study

Objectives: Secondary prevention of ischaemic heart disease (IHD) is very important. This study aimed to assess knowledge of necessary lifestyle changes among Omani patients diagnosed with IHD. Methods: This cross-sectional pilot study took place between October 2015 and February 2016 at the Sultan Qaboos University Hospital (SQUH), Muscat, Oman. A total of 30 random patients with IHD from the Cardiology Outpatient Clinic of SQUH were included. A 30-item survey was used to determine patients’ knowledge of necessary lifestyle practices following their IHD diagnosis, with scores of &lt;70% indicating poor knowledge. Results: Overall, 21 patients (70.0%) had low knowledge levels. Scores ranged from 38.9−94.4% (mean: 60.7% ± 14.1%). No demographic factors were found to predict low scores, although there were some differences in individual questions. Conclusion: Low knowledge levels regarding lifestyle changes were observed among IHD patients in Oman. More efforts should be made to educate these patients for the secondary prevention of IHD

Micromirror Angle Dependence with Etchant Choice on <100> Silicon Via Wet Etching

In creating mirrored silicon structures for micro-optics, the smoothness of the surface and etch rate are crucial parameters. We demonstrate a method of creating both 45° and 90° etch-planes from monocrystalline silicon for use as retro-reflective sidewalls in a microfluidic device. The technique uses the same photolithographic pattern orientation, but with two different etchants. Etching on direction in Si(100) with potassium hydroxide (KOH) gives vertical surfaces (where e.g. the high surface tension influences etching of crystallographic silicon planes), whilst tetramethylammonium hydroxide (TMAH) gives 45° sidewalls. We illustrate the use of these fabricated structures by creating arrays of micromirrors that enable an optical beam to be reflected parallel back and forth from 45° and -45° tilted vertical structures. This device has potential uses in optofluidic spectroscopic applications, where there is a need to increase the effective pathlength of a beam through a sample whilst keeping the device as small as possible

Micromirror Angle Dependence with Etchant Choice on <100> Silicon Via Wet Etching

In creating mirrored silicon structures for micro-optics, the smoothness of the surface and etch rate are crucial parameters. We demonstrate a method of creating both 45° and 90° etch-planes from monocrystalline silicon for use as retro-reflective sidewalls in a microfluidic device. The technique uses the same photolithographic pattern orientation, but with two different etchants. Etching on &lt;;100&gt; direction in Si(100) with potassium hydroxide (KOH) gives vertical surfaces (where e.g. the high surface tension influences etching of crystallographic silicon planes), whilst tetramethylammonium hydroxide (TMAH) gives 45° sidewalls. We illustrate the use of these fabricated structures by creating arrays of micromirrors that enable an optical beam to be reflected parallel back and forth from 45° and -45° tilted vertical structures. This device has potential uses in optofluidic spectroscopic applications, where there is a need to increase the effective pathlength of a beam through a sample whilst keeping the device as small as possible

An Effective Knowledge-Based Modeling Approach towards a “Smart-School Care Coordination System” for Children and Young People with Special Educational Needs and Disabilities

There is a significant need for a computer-aided modeling, effective information analysis and ontology knowledge base models to support both special needs children and care providers. As this research work correlated to the symmetry scope, it proposes an innovative generic smart knowledge-based “School Care Coordination System” (SCCS), which is established on a novel holistic six-layered data management model. The development of the Smart-SCCS adopts a methodology of ontology engineering to transform the given theoretical unstructured special educational needs and disabilities (SEND) code of practice into a comprehensive knowledge representation and reasoning system. The intended purpose is to deliver a system that can coordinate and bring together education, health and social care services into a single application to meet the needs of children and young people (CYP) with SEND. Moreover, it enables coordination, integration and monitoring of education, health and social care activities between different actors (formal, informal and CYP in the education sector) involved in the school care process network to provide personalized care interventions based on a predefined care plan. The developed ontology knowledge-based model has been proven efficient and solved the enormous difficulties faced by schools and local authorities on a daily basis. It enabled the coordination of care and integration of information for CYP from different departments in health, social care and education. The developed model has received significant attention with great feedback from all the schools and the local authorities involved, showing its efficiency and robustness

Identification of Klebsiella oxytoca by VITEK-2 System in Baghdad Hospitals

Background: Klebsiella oxytoca is a Gram-negative rod-shaped bacterium that is becoming resistant to multiple drugs and is frequently endangering patients' lives. It is a member of the human microbiota. Objectives: To assess the value of identifying K. oxytoca using an automated diagnostic system (VITEK-2) as compared to traditional manual methods. Materials and Methods: A total of 136 clinical specimens were collected from patients in Baghdad hospitals during a period from July to November 2022. VITEK-2 system was used to recognize the isolated bacteria to the genus and species level. The biochemical indole test was used as a confirmatory test at the species level. Results: K. oxytoca was more common in urine samples 49 (36.0%) followed by blood samples 21 (15.4%). Of the total collected samples 77 (56.6%) were from inpatients and (43.3%) were from outpatients. The primary identification by cultural and microscopic examinations diagnosed all the isolates as Klebsiella. VITEK-2 system recognized them as K. pneumoniae. The indole test confirmed the species as K. oxytoca by the formation of the red ring. Conclusion: using a simple biochemical test like indole is crucial in clinical laboratories to investigate the accuracy of bacterial identification at the species level. Continuous evaluation for the identification results of the automated systems is needed and can be done by updating the system software for the new emerging pathogens in the hospitals.     Received June. 2022 Accepted Sept. 2023 Published Jan. 2024